Major League Baseball has decided not to hold regular-season games in San Juan, Puerto Rico, and Mexico City in 2025 due to economic concerns, as stated by commissioner Rob Manfred. The only international games next year will be two opening games in Tokyo featuring the Chicago Cubs and Los Angeles Dodgers.

Manfred expressed hopes for future arrangements in San Juan while emphasizing the league's focus on Tokyo for business reasons. The current collective bargaining agreement allows for potential international games, but financial viability remains a key factor in planning.